Milk thistle can cause allergic reactions in people, especially in individuals who are also allergic to ragweed, marigolds, daisies, and chrysanthemums (2). On extremely rare occasions, milk thistle has caused severe allergic reactions as well as anaphylaxis, a potentially life-threatening allergic reaction. Copyright 2011 - 2023 IncNut Stylecraze Private Limited. JAMA. You might also get the herb at your nearest supermarket/pharmacy. The active ingredient in milk thistle, silymarin, acts as an antioxidant by reducing free radical production. Does Milk Thistle Capsule interact with other medications? Is there also a role for herbs and supplements? 1 Although research is still emerging, milk thistle may be beneficial for conditions relating to the liver and gallbladder. Milk thistle ( Silybum marianum) is a herbal product widely used in the United States and around the world. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. Milk thistle might also decrease hormone levels in the body (5). Allergic reactions, abdominal problems, and estrogen and drug interactions are some of the common side effects seen in people who take this herb for extended durations. Studies of milk thistle coadministered with various drugs in humans suggest it is unlikely to affect the most common cytochrome, the P450 (CYP450) isozyme. Achufusi TGO, Patel RK. These side effects may be mild or severe. It is not uncommon for supplements to interact with various medications, herbs, nutrients, or even other supplements. The mention of any product, service, or therapy is not an endorsement by NCCIH. Potensi Tinggi Setiap kapsul mengandung 1.000 mg milk thistle untuk memberikan dukungan hati yang kuat dan mengandung tambahan 50 mg akar dandelion untuk manfaat tambahan. 1997-. Last medically reviewed on December 17, 2021. Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first. Follow all directions on the product package. Does milk thistle interact with my other drugs? Common side effects of milk thistle may include: indigestion, bloating, gas, stomach pain; diarrhea; or. Use milk thistle as directed to prevent an overdose. Phytother Res. Include all brand names and combination drug names. Learn, Medical News Today has strict sourcing guidelines and draws only from peer-reviewed studies, academic research institutions, and medical journals and associations. How long does it take for milk thistle to start working? Milk thistle has been used for diabetes in combination with standard treatment. Tajmohammadi A, Razavi BM, Hosseinzadeh H. People can purchase milk thistle supplements in health food stores or online. It also seems to have antioxidant and anti-inflammatory effects. Loose stools or upset stomach may occur. Finally, those with hormone-sensitive conditions, including certain cancers, may need to avoid using milk thistle. If you notice other effects not listed above, contact your doctor or pharmacist. For guidance from NCCIH on using PubMed, see How To Find Information About Complementary Health Approaches on PubMed. Yes, you can drink alcohol while taking milk thistle. To establish that the product manufacturers addressed safety and efficacy standards, we: We do the research so you can find trusted products for your health and wellness. Consult your doctor before using this product. Highly clinically significant. You should follow dosage directions to prevent side effects. Milk thistle (Silybum marianum) is a herb loaded with antioxidants and is known for its anti-inflammatory properties. Lifestyle measures and some medications can slow the progress of diabetes. 3 are moderate, and 1 is minor. We know little about whether milk thistle is effective in people, as only a few well-designed clinical studies have been conducted. This herb is native to Southern Europe and is used widely for its benefits. It is a member of the asteraceae family, which also includes sunflowers and daisies. MNT is the registered trade mark of Healthline Media. We link primary sources including studies, scientific references, and statistics within each article and also list them in the resources section at the bottom of our articles. Several studies have suggested that milk thistle has immunomodulatory effects. Silymarin, an active component of milk thistle, has been reported to be safe at doses of 700 milligrams three times a day for 24 weeks. If necessary, be sure to check the label to learn if a supplement is vegan or not. Brittany Lubeck, RD, is a nutrition writer and registered dietitian with a master's degree in clinical nutrition. It is not intended to substitute for the medical expertise and advice of your health care provider(s). Some of the studies have been of poor quality, too. Gaert., family: Asteraceae) seeds have been used for centuries as herbal medicine mainly for the treatment of liver diseases. Milk thistle may help strengthen a persons immune response. When looking at Milk Thistle itself (prior to any extraction), the fruits or thistles contain: Silymarin at 1.5-3% of dry weight (to be elucidated later) [2] Silyhermin and both Neosilyhermin A and B [2]; Protein and Mucilage (taking up 25-30% of the herb by dry weight) [2] Quercetin and the dihydro varient known as Taxifolin [2]; Kaempferol, Dihydrokaempferol, and the 7-glucoside and 3 . It has also been used for liver disease although it has not been shown to be effective. Common side effects of milk thistle reported in studies include: Typically, side effects will subside once you stop using milk thistle. Researchers must carry out more studies on humans to confirm the effects of milk thistle on cognition. He has been in the digital media field for over eight years. Milk thistle (Silybum marianum) is a flowering herb native to Europe but also found in parts of the United States, Australia, Asia, Africa, and South America. In Canada - Call your doctor for medical advice about side effects. It may not be safe for people with hormone-sensitive breast cancer. doi:10.1002/14651858.CD003620.pub3. 2011;17(18):2288-2301. doi:10.3748/wjg.v17.i18.2288. Avoid combinations; the risk of the interaction outweighs the benefit. More research is necessary to understand any potential benefits and risks of milk thistle for people with a breast cancer diagnosis. No supplement is intended to treat, cure, or prevent disease. Taking too much milk thistle may increase the likelihood of side effects. However, if you develop an allergic reaction after taking milk thistle, stop use and consult your doctor. Effect of silymarin on biochemical indicators in patients with liver disease: systematic review with meta-analysis. 2015;22(2):290-296. doi:10.1016/j.phymed.2014.12.010. Hence, limit its usage if you experience any adverse reactions. Check with your pharmacist for more details about the brand you use.The FDA has not reviewed this product for safety or effectiveness. Milk thistle for alcoholic and/or hepatitis B or C liver diseases--a systematic Cochrane hepato-biliary group review with meta-analyses of randomized clinical trials. Silymarin is an active compound found in milk thistle seeds. However, seek immediate medical attention if you notice any of the following symptoms of a serious allergic reaction: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Herbal product use by persons enrolled in the hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial. Liquid forms of this product may contain sugar and/or alcohol. Phytomedicine. Further, while liver-related mortality was significantly reduced by milk thistle, this was not seen in any of the high-quality trials. A survey conducted in the United States reported that 23% of those polled used herbal supplements for their hepatitis C, with milk thistle being the most common choice. Some, but not all, milk thistle supplements are vegan. Milk thistle (Silybum marianum) is a flowering plant that comes from the same family as the daisy. Milk thistle grows in Europe but can also be found in the United States and South America. Milk thistle ( Silybum marianum L. Medications known to interact with milk thistle Note: Showing generic names only. The content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Rev Diabet Stud. 2005;100(11):2583-91. doi:10.1111/j.1572-0241.2005.00262.x. By Brittany Lubeck, RD The Food and Drug Administration (FDA) has not approved milk thistle for the treatment of cancer. *. increased sweating. Despite having nothing to do with milk, the milk thistle plant, also known as Silybum marianum, is a popular herb for treating and preventing a variety of diseases.. Occasionally, people report various digestive side effects. You can learn more about how we ensure our content is accurate and current by reading our. Historically, people have used milk thistle for liver disorders and gallbladder problems. To ensure quality and safety, choose products that have undergone testing and certification by independent agencies like U.S. Pharmacopeia (USP), ConsumerLab, and NSF International. Enter other medications to view a detailed report. NCCIH has provided this material for your information. Calm an upset stomach. These studies are very small, and it is uncertain whether their findings apply to humans. Eur Endocrinol. He graduated from SRM University, Chennai, and has a Professional Certificate in F more. Keep all medications and herbal products away from children and pets. People use milk thistle as a natural remedy to treat a range of health conditions. 2014;11(2):167-74. doi:10.1900/RDS.2014.11.167. Hence, stay safe and avoid use. Duplication is encouraged. Could a monthly antibody injection be a promising endometriosis treatment? hepatitis. Thank you, {{form.email}}, for signing up. J Diabetes Res. Does Milk Thistle Capsule interact with other drugs you are taking? Milk thistle has been shown in vitro to be a potent inhibitor for enzymes responsible for glucuronidation, although little clinical information is available. The milk may have fallen on the leaves, leaving white marks. But it may be a helpful complementary treatment to try if a healthcare professional approves it. Our team thoroughly researches and evaluates the recommendations we make on our site. 1982;17:51721. Dupuis ML, Conti F, Maselli A, et al. You may report side effects to FDA at 1-800-FDA-1088. Effects of vitamin E on chronic hepatitis C genotype 3: a randomized, double-blind, placebo-controlled study. Milk thistle may produce allergic reactions, which tend to be more common among people who are allergic to plants in the same family (for example, ragweed, chrysanthemum, marigold, and daisy). Milk thistle (silymarin) is a flowering herb related to the daisy and ragweed family. Silybum (milk thistle) is a genus of two species of thistles in the family Asteraceae. Results from clinical trials of milk thistle for liver diseases have been conflicting or havent been clinically meaningful. Click here for additional information. Milk thistle may cause an allergic reaction in those with allergies to plants in the same family, like ragweed, chrysanthemum, marigold, and daisy. (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: a randomized, triple-blind, placebo-controlled clinical trial. Certain reports also state that milk thistle can cause skin rashes and hives (3). People with diabetes should use caution. Ask your doctor or pharmacist about using this product safely. [1] Silymarin is a standardized preparation extracted from the fruits (seeds) of milk thistle. So, consult a doctor to understand about its long term usage. Horn and Hansten are both professors of pharmacy at the University of Washington School of Pharmacy. Can Apoaequorin Really Improve Your Memory? 3. Other potential benefits include . However, researchers theorize that it does. Talk to your pharmacist for more details. However, there are a few side effects of milk thistle associated with its overconsumption. Consult your doctor or pharmacist for more details. Milk thistle may help to stop the spread of certain types of cancer. 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